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Pax9 mediated cell survival in oral squamous carcinoma cell enhanced by c-myb
Pax9 mediated cell survival in oral squamous carcinoma cell enhanced by c-myb
Pax9 mediated cell survival in oral squamous carcinoma cell enhanced by c-myb
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Paired box gene 9 (Pax9) and c-myb are transcription factors that regulate the expression of the genes involved in mediating cell proliferation, resistance to apoptosis, and migration. However, the function of Pax9 in oral squamous cell carcinoma (OSCC) is virtually unknown. This study examined the anti-apoptotic roles of Pax9 and c-myb, and clarified interaction between the two genes in KB cells. Inhibition of Pax9 caused the induction of apoptosis with enhanced cleavage of caspase-3 and PARP, accelerated Bax, and reduced Bcl-2 expression. Transducing c-myb cells with adenovirus c-myb (Ad/c-myb) were induced cell growth and inhibited apoptosis, but dominant-negative myb cells (Ad/DN-myb) were not affected. Pax9 was upregulated in the Ad/c-myb cells with simultaneous decrease in the Ad/DN-myb infection. However, c-myb remained unaffected in the Pax9 small interfering RNA (siRNA) transfected cells. Moreover, the Pax9 siRNA transfected cells and Ad/DN-myb infected cells were able to arrest the cell cycle at the G0 phase. This suggests that Pax9 and c-myb expression in KB cells is essential for cell growth, and survival is enhanced by c-myb. Disrupting the function of c-myb and Pax9 could be a potential target for cancer treatment. Copyright © 2008 John Wiley & Sons, Ltd.
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| • | Tiny Protein Provokes Healthy Bonding Between Cells | |
| In human relationships, a certain "spark" often governs whether we prefer one person to another. Critical first impressions can occur within seconds. Researchers have found that cell-to-cell "friendships" operate in much the same way and that dysfunctional bonding is linked to the spread of cancer. | ||
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| A new study from Georgia Tech shows that when patients with macular degeneration focus on using another part of their retina to compensate for their loss of central vision, their brain seems to compensate by reorganizing its neural connections. | ||
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| • | Making mouse knockouts en masse, the science of sun tanning, and silencing jumping genes | |
| Includes interviews with Dr Francis Collins on the international mouse knockout program, Dr David Fisher on the role of p53 in tanning, and Dr Greg Hannon on pi RNAs silence transposons in the fly genome. | ||
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| • | Cell Graphics, biological illustrations and graphics of cells and ... | |
| CELL PICTURES: Picture of an Animal Cell, Plant Cell (Eukaryotic / Eucaryotic cells) ... Red Blood Cells or Erythrocytes: Obesity: Fat Cells or Adipocytes: NEW at RKM! | ||
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| • | Triplantanol increases plant cell growth | |
| Plants that are growing most vigorously exhibit the most noticeable effect on leaf growth. There can be both length and width increases in plant leaves. This is often accompanied by increased thickness and robustness. Leaves can become more fuller and more rounded according to leaf form and plant type. See the pictues on our site (Bigger leaves) showing how leaf shape has been changed in Geraneum plants | ||
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Cell Biochemistry and Function
By John Wiley & Sons, Inc - Copyright © 2008 John Wiley & Sons, Ltd. - version: v1.5 build A
By John Wiley & Sons, Inc - Copyright © 2008 John Wiley & Sons, Ltd. - version: v1.5 build A